Exploring the 3D Genome: Twist, Fold, Solve

DNA inside your cells is not simply a long, straight molecule. It folds into complex three-dimensional structures, and this spatial organization plays a critical role in gene regulation, cell behavior, and genome function. Understanding chromosome architecture and 3D genome organization remains a major challenge in modern genomics and computational biology.

In this interactive scientific visualization game, you will work with fragments of a 3D chromosome along with Hi-C inspired data-driven clues that describe how different genomic regions should relate to one another. Your task is to reposition and assemble these regions until the chromosome achieves its correct structural configuration through spatial reasoning and interactive exploration.

3DChromoTwist combines gamification, bioinformatics education, and human-computer interaction principles to create a serious game for learning chromosome reconstruction, chromatin organization, and spatial genomics. In addition to its educational role, the platform also serves as a foundation for future research in interactive and human-guided approaches to genome structure reconstruction and scientific visualization.

The structures used in the game are based on real experimental data, providing an authentic and educational experience.